Mapping of the melatonin receptor 1a (MTNR1A) gene in pigs, sheep, and cattle.

نویسندگان

  • L A Messer
  • L Wang
  • C K Tuggle
  • M Yerle
  • P Chardon
  • D Pomp
  • J E Womack
  • W Barendse
  • A M Crawford
  • D R Notter
  • M F Rothschild
چکیده

and Implications Human and sheep Melatonin receptor 1a (MTNR1A) gene information was used to clone a portion of the coding region of this gene in pigs, and to identify polymorphisms of the gene for its assignment to both the genetic linkage and physical maps. MTNR1A maps to pig chromosome 17, establishing a new region of conserved synteny between this chromosome and human chromosome 4. Furthermore, we have assigned MTNR1A to bovine chromosome 27 and sheep chromosome 26. The addition of genes like MTNR1A to livestock genome maps allows questions about evolutionary events and the genetic basis for quantitative traits in livestock to be addressed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Association of Melatonin Receptor 1A Gene Polymorphisms with Production and Reproduction Traits in Zandi Sheep

Melatonin regulates some major physiological processes such as maturation and function of reproductive system, pubertal development, seasonal reproduction and adaptation. The activation of melatonin hormone is mediated by melatonin receptor. Previous studies showed melatonin receptor 1A gene (MTNR1A) is highly polymorphic in seasonally breeding species. The aim of the present study was detectio...

متن کامل

Genetic Polymorphism of the Melatonin Receptor 1A Locus in Iranian Shall and Karakul Sheep

The genotypes of the melatonin receptor 1A (MTNR1A) were determined by PCR-RFLP in the native Iranian Shall  and karakul breeds of sheep . Blood samples were collected from 60 karakul and 50 Shall breeds. Genomic DNA was extracted based on the Guanidin Thiocyanate-slica gel method. After PCR reaction, PCR products were digested by the Mnl1 restriction enzyme. The MTNR1A locus had two genotypes ...

متن کامل

Association between Melatonin Receptor 1A (MTNR1A) Gene Polymorphism at the MnlI Site and Production Traits in Shal and Crossbreeding between Shal and Romanov

The objective of this study was to evaluate the relationship between polymorphism at the MnlI site of MTNR1A gene and production traits of Shal and Romanov crossbreeding. The crossbreeding between Shal and Romanov was done on 600 Shal ewes. For this reason, Shal ewes were laparoscopically and artificially inseminated with the semen of Romanov breed. For the preparation of genomic DNA, a total o...

متن کامل

Association between MTNR1A and CYP19 Genes Polymorphisms and Economic Traits in Kurdi Sheep

The ovine melatonin receptor 1A (MTNR1A) and aromatase (CYP19) genes were structurally characterized and the association between their variants and reproductive and growth traits was studied in Kurdi sheep at Kurdi sheep breeding station located in Shirvan, Iran. The genomic DNA was extracted by guanidine thiocyanate-silica gel method. Polymerase chain reaction was carried out to amplify 824 bp...

متن کامل

Polymorphism of the Melatonin Receptor 1A Gene and Its Association with Litter Size in Zel and Naeini Sheep Breeds

The influence of melatonin receptor 1A gene on litter size was studied in 150 ewes from Zel (n=100) and Naeini (n=50) sheep breeds. Two restriction fragment length polymorphism (RFLP) analyses were done to determine all genotypes occurring by variations at MnlI and RsaI restriction sites. The M and C were the most frequent alleles in both of these breeds. The MM genotype was predominant in Zel ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Mammalian genome : official journal of the International Mammalian Genome Society

دوره 8 5  شماره 

صفحات  -

تاریخ انتشار 1997